The Dushthana houses and their domain over the sickness and misfortune-
• Houses 6, 8, and 12 are the dushthana houses or houses of suffering and difficulties.
• The 3rd house is also considered as a dushthana, but with a milder effect (the 3rd is the 8th from the 8th).
• Those houses are adverse to the material prosperity and well-being and the planets placed in those houses and the houses they rule tend to suffer, be obstructed, and be sources of pain in life.
• The people or parts of the body that the planets placed on those houses represent will tend to be a source of pain.
• If the planets paced here are exalted or in their own house, it is actually beneficial and gives the capacity to endure or overcome pain and difficulties.
• The 6th house relates to obstacles, diseases, accidents, enemies, and debt.
• The 8th house relates to obstruction, death, darkness, or depression.
• The 12th house relates to loss, separation, and endings.
• In spite of that, they are also important houses for spiritual growth, and if they are strong and well-disposed they represent the capacity to practice Yoga and liberate from pain.
The Maraka houses
• The 2nd and 7th houses are called the Maraka or "killer" houses and have the capacity to cause death or disease.
• Usually, the death o a person is during the Maha Dasha or Antar Dasha and/or transits of a planet placed or associated with those houses or the ruler of those houses.
• The ruler of the 8th, 12th and 3rd houses or planets placed on those houses are also capable of causing death.