Combinations of having no progeny as per Lagu Prashari.
1.5th lord in 8th makes it difficult to sire progeny.
2.Debilitated 5th lord and mars in 5th in sign Sagittarius.
3.Debilitated 5th lord and Mars debilitated in 5th.
4.5Th lord debilitated and also the debilitated 7th lord
5.5th and 6th lord conjunct and Jupiter in Sagittarius.
6.Debilitated planet in 5th and 5th lord debilitated.
7.5th sign aries and Jupiter in Aries along with Mercury. ( Aries is a barren sign)
8.Rahu in 5th and jupiter+mars with 5th lord.
9.Debilitated planet in 5th and 5th lord combust.
10.Rahu and Jupiter in Aries or Jupiter Mars in Aries.
11.5th lord Mars and Jupiter in Sagittarius in 5th.